Spectrum's Tangential Flow Filtration (TFF) easily and directly scales up for the pilot production of large volume applications. The hollow fiber geometry of KrosFlo modules allows you to simply factor up the membrane surface area, the circulation rate and the filtration rate established in process development, by the same factor, while maintaining the operating pressures and the overall process time. Combined with the disposability of Spectrum's membranes for easy validation, the NEW KrosFlo Pilot Plus System is ideal for diagnostic and biopharmaceutical pilot production for FDA validated processing.
The NEW KrosFlo Pilot Plus is manufactured under cGMP standards for the tangential flow filtration of validated pilot production processes. The system is provided with complete GMP documentation and is UL, CE and CSA certified. The KrosFlo Pilot Plus System consists of a Waukesha rotary lobe pump to circulate process streams through an adjustable stainless steel flow-path that is adjustable for the incorporation of any length pilot and production scale Spectrum hollow fiber modules or retrofit. The unique carting design includes 4 locking caster wheels to provide system mobility while the leveling pads assure system stability during operation. Three system models are available depending on the required processing capacity.
Four system models for different volume capacities:
|Typical Process Volume||Pump Capacity @ 2 Bar||SS Flow-path||Manifolds available||Hollow Fiber Modules|
|10 -150 liters||25 LPM||3/4" Dia.||Single or Double||KF|
|50-500 liters||75 LPM||1.5" Dia.||Single or Double||KF|
|250-2000 liters||200 LPM||2" Dia.||Single or upto four modules||KF & KF Max|
|1000-5000 liters||350 LPM||2.5" Dia.||Single or upto four modules||KF & KF Max|
Standard System includes:
Optional features and accessories:
Advantages of Disposability
KrosFlo® Pro-Connex Fittings
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